Special Settings for Anime/Cartoon & CGI

Well as cartoons and animated(CGI) is setup in a different way you would have to change some of the settings in the commandline i will give some pointers where you can work your way from.
[edit] Anime/Cartoon

Reference Frames can be really effective with animated/cartoon as many frames can be referred to. with 720p just aim for a ref number that is L4.1 Compatible. 1080p can use as much as 10 reference frames just note that if you go above 4-5 ref frames the encode will no longer be L4.1 Compatible.

--ref 9

Psy-rdo Can be used but remember to keep it lowere than usual as it can create artifacts.

--psy-rd 0.6:0.0 

It will be a good idea to test between trellis 0 and trellis 2 as it can hurt picture quality.

--trellis 0

And you also want to lower or even disable Adaptive Quantizers(AQ) it depends on how dirty your source is or if you see visible blocks.
Disable

--aq-mode 0

Enable

--aq-strength 0.6

[edit] Animated(CGI)

Animated requires at times some additional tweaking than a cartoon would.

You can use psy-rdo at low values i would recommend keeping it under 1.0 Trellis should normally be tested with both 0-2. You can also use a low AQ between 0.5-0.9. Disable dct-decimate on very sharp/detailed sources (but that requires a bit more bitrate, so it's not appropriate for bitrate-starved encodes). Raise the reference frames. Also disabling Weighted Prediction can help out getting more detail. to disable that remove this command from your encode script --weightb Also ref frames can be helpful as high as 10 ref with 1080p doing this though will make your encode L5.0 instead of L4.1

--ref 9
--trellis 0/2
--psy-rd 0.9:0.0
--aq-strength 0.7
--no-dct-decimate